Results
| PMID | 25063483 |
| Gene Name | IL1B |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 603 |
| Population details | 603 (510 women with histologically proven endometriosis, 93 endometriosis-free controls) |
| Sex | Female |
| Associated genes | IL-1?, IL-1sRII |
|
J Gynecol Obstet Biol Reprod (Paris). 2014 Nov;43(9):735-43. doi: Lambert, S| Santulli, P| Chouzenoux, S| Marcellin, L| Borghese, B| de Ziegler, D| Batteux, F| Chapron, C Departement de gynecologie obstetrique et medecine de la reproduction, faculte de medecine, universite Paris Descartes, Sorbonne Paris Cite, hopital Cochin, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France. Electronic address: lam OBJECTIVES: To assess interleukin-1beta (IL-1beta) and its inhibitory soluble interleukin-1 receptor type II (IL-1sRII) levels into the serum of patients with various forms of endometriosis and normal women, and investigate the correlation with disease activity. PATIENTS AND METHODS: In this prospective laboratory study (2005-2010), 510 women with histologically proven endometriosis and 93 endometriosis-free controls have been enrolled. Laparoscopic complete exploration of the abdominopelvic cavity and blood samples have been performed in each patient. For each serum, IL-1beta and IL-1sRII have been evaluated using Elisa. RESULTS: IL-1beta and IL-1sRII have been respectively detectable in 64% and 54.6% of serum samples from all 603 women studied. IL-1beta was higher in women with deep infiltrating endometriosis (DIE) (mean 10.0pg/mL [0.005-416.2]) than in endometriosis-free women (mean 0.5pg/mL [0.01-1.7], P<0.01) or in women with superficial endometriosis (SUP) (mean 0.6pg/mL [0.1-2.9], P<0.01). Also, IL-1sRII was higher in DIE (mean 236.7pg/mL [0.9-6975]) than in the witness group (mean 85.0pg/mL [1-235.2], P<0.05) or in SUP (mean 85.1pg/mL [0.6-302], P<0.01). CONCLUSION: This study highlights both a marked significant increase in serum IL-1beta and IL-1sRII levels in DIE compared to SUP and normal women and suggests that a defect in the control of IL-1 can impact the pathophysiology of endometriosis. Mesh Terms: Adult| Endometriosis/*blood/*pathology| Enzyme-Linked Immunosorbent Assay| Female| Humans| Interleukin-1beta/*blood| Prospective Studies| Receptors, Interleukin-1 Type II/*blood|DA 2015/07/24 06:00 |
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